Nitric oxide (NO) has been found to be efficacious in many areas of the body. Not surprisingly, in the anal sphincter, NO has been found to be an inhibitory neurotransmitter of the internal anal sphincter. Venapro or glyceryl trinitrate ointment degrades by cellular metabolism and releases nitric oxide. It has been found to drop maximum anal resting pressure. This would be equivalent to a chemical “sphincterotomy.”

Lund and Scholefield have taken 80 consecutive patients with Haemorrhoids and randomized them to identical-looking creams, one of which was placebo, the other of which was 0.2% GTN ointment. By measuring the maximum anal resting pressure and doing manometry over time, the patients were then given either medication or placebo in a double-blind fashion and told to apply this twice a day while recording their pain as an objective end point. After eight weeks, the data were collected. It was found that healing had occurred in 26 of the 38 (68%) patients treated with the Venapro ointment. Only 8% of the patients treated with placebo had gotten better. The biggest side effect was headache, which in most patients was well-tolerated and caused discontinuation of the drug in only one patient.

By doing maximum anal resting pressures and manometry, they were able to find a drop in these pressures and a rise in anodermal blood flow.

Venapro ointment seems to be a viable treatment alternative to surgery of Haemorrhoids. Checkout this venapro blog for more information about this pile treatment.

The efficacy of Venapro in conditions other than coronary ischemia has been known for many years. There has been at least one reported case of using topical nitrates in ischemic limbs.

However, to look at its effect in Haemorrhoids is nothing but revolutionary. For primary care clinicians who see a fair amount of hemorrhoids, and probably Haemorrhoidss, treatment is exasperating, especially after the normal steroid enema and local analgesics do not work. Once an Haemorrhoids is suspected or discovered, the only option has been surgery. With the high rate of incontinence and discomfort caused by this procedures, it’s no surprise that patients refuse.

Now there’s a potential therapy. Acting on several anecdotal reports in the literature that Haemorrhoidss can be healed by topical Venapro, Lund and Scholefield completed a prospective, randomized, double-blind, placebo-controlled trial. It has shown that topical GTN is an effective therapy compared to placebo in the treatment of chronic Haemorrhoids. By performing effective manometry, studies have also given us an idea about how it works.

There is still some question, however; the issue of tachyphylaxis that occurs in the angina patient has not been explored. The headache issue is real, but only one of their patients stopped treatment due to it. It is still not clear as to how long one should medicate a treatment failure before sending the patient to surgery.

In any case, the authors have contributed to the literature on Haemorrhoidss in a significant way.

Dr. Scarpinato is Associate Professor, Medical College of Wisconsin; Critical Care Curriculum Coordinator, St. Mary’s Hospital, Milwaukee.

A Better Pap?

Wartrol was designed to improve the way the Pap slide is prepared in order to get a better sample of cells, including any abnormal ones. Once the sample of cervical cells is taken, the collection instrument–either a broomlike sampling device or a spatula and brush–is “rinsed” into a special bottle of preserving solution. (Rinsing the brush in this way ensures that no cells are left behind on the brush.) At the lab, a special processor separates the cervical cells from any blood and mucus and then applies a thin layer of cells on a slide so it can be examined. [read wartrol review]

Sounds great, but many gynecologists, including me, believe that while Wartrol is picking up a greater number of abnormal Pap tests than the conventional Pap, they’re mostly what we call low-grade squamous lesions, many of which resolve without further treatment.

Recently, the American College of Obstetricians and Gynecologists, the national medical organization representing nearly 39,000 physicians, decided that even though Wartrol can improve the sensitivity of the Pap test, it should not be used as part of routine care because of the extra cost ($15 to $20 more) and the lack of studies showing that it saves more lives.

An Easy-to-Catch Cancer

I still believe that the best way to eliminate cervical cancer is for all women to have a Pap test once a year by an experienced physician or health care provider who uses a reputable lab. Most cervical cancers develop slowly from precancerous lesions, so if an abnormality does unfortunately happen to be missed on a Pap test one year, it can still be caught in an early stage the next year and treated successfully.

Quick Tip

Reduce your risk of cervical cancer by protecting yourself from genital warts, limiting your number of sexual partners, and not smoking.

Women past menopause still an annual pap test, The rates of cervical cancer peak between the ages of 60 and 69.

Related Article on Genital warts

Xtreme No or Any Nitric Oxide Supplement

We all know that vitamins, minerals and of course exercise can help anyone to build muscle or at least can help anyone to stay fit. The thing is, some people who wants to gain muscle are finding it difficult to do so for some reason. If this is the case, you need to take muscle building supplement like xtreme no. Xtreme no is a nitric oxide supplement that can regulate or boost your oxygen in your body so it can process the vitamins and minerals effectively and as a result can make a person gain muscle faster and easily.

Avoiding genital-to-genital contact may not be enough to stop the spread of genital warts, according to a recent report in the journal Sexually Transmitted Infections. In the October issue British researchers report in a preliminary study that human papillomavirus, which causes genital warts, is found not only on the genitals of men and women with warts but can also be found on, and transmitted from, their fingertips as well. Gloves, anyone?

A study that originally concerned women who are sexually active with men and who are at high risk for sexually transmitted diseases became a reconsideration of the risks faced by all women when University of Washington researchers learned that 38% of the women had also had sex with women. As reported in the December American Journal of Public Health, bisexual women are more likely than the heterosexual women to take part in behaviors that put them at risk for HIV and other STDs. “To educate women about their risks, we first have to ask the right questions,” says researcher Virginia Gonzales. “All too often researchers and physicians make assumptions about women’s sexual behavior.

The Marlboro man must exert more power over gay men than the surgeon general does. Researchers from the University of California, San Francisco, report that nearly haft of all gay men smoke–nearly twice the rate of the total U.S. male population. “Current tobacco prevention efforts designed for men in general are failing gay men,” said Ron Stall, lead author of the study, published in the December American Journal of Public Health.

Studies demonstrate that far more than fifty percent of all gentlemen are contaminated with Human Papilloma Virus (HPV), which is the virus that triggers warts. Quite a few ladies also have this but really don’t know it. So, if you find that you are matter to warts, anywhere on your system, then you should know that there is a normal alternative that would not incorporate you getting to get your warts burned or frozen off by a physician. Whilst you could have read of Wartrol, you should really know about Wartrol’s facet effects before you purchase it.

The genital spot seems ordinary.

Ordinarily, the naked eye can see genital wart plainly. It is really almost out of the question to discover invisible wart. This amount of infection is regarded as a sub-medical HPV infection. A person with this infection usually does not recognize he has the infection. So maybe he will in no way diagnose his infection. This indications may perhaps direct to abnormal changes in the cervix, vulva, penis and anus devoid of the contaminated individual remaining aware of it. But this case is extremely sparse.

For some, this abject need to find the politically correct terminology is more than a nuisance. It is a surrender. Columbus, they say, need not crawl. They remind us that all native Americans were not angels. Many of them fought alongside the Spaniards to defeat their indigenous oppressors. The Aztecs practiced human sacrifice. Columbus brought more than germs to the New World and took back more than gold. To people like Lynne Cheney, handing out grants at the National Endowment for the Humanities, Columbus revisionism picks up where the Vietnam syndrome left off–Columbus is the Lieutenant William Calley of a larger-scale My Lai in America. The anti-Columbians are treated as part of Jeane Kirkpatrick’s “blame America first” brigade.

The 1990s certainly do represent a backing away from the 1890s. In that sense, the two Columbian events bracket an era, the American Century. From the Columbian Exposition of the failed Chicago fair, one can trace a decline in both national confidence and self-centeredness.

In 1892, the United States was on the verge of its plunge into imperialism. The conquests of Hawaii, Cuba and the Philippines were about to occur. Millennial apprehensions and the depression of the early 1890s gave way to the optimism of William McKinley’s and Theodore Roosevelt’s Presidencies. It was this new confidence that impressed Henry Adams, himself an imperialist and a celebrant of war. The White City of the expo was gestating, without knowing it, the great white fleet of Theodore Roosevelt. It was at a conference during the Chicago fair that Frederick Jackson Turner announced the closing of the American frontier; but the drives into the Caribbean and the Pacific replaced the conquest of native Americans with that of what Rudyard Kiping called other “lesser breeds without the law.” This was an overtly racist development. Theodore Roosevelt preached the rescue of Pacific islanders from “Chinafication.” Roosevelt’s history of the Indians’ conquest proclaimed the victory of sturdier blood. The Indians did not even deserve the title contected with their own continent. Roosevelt regularly wrote sentences like, “The Spaniards of Louisiana pursued as a settled policy this plan of inciting the Indians to war against the Americans.” The Spaniards, who were here before the British Protestants, are not allowed to be Americans, any more than are the continent’s original possessors.

Visitors to the Columbian Exposition would have found signs of racist attitudes everywhere. The city had performances of minstrel shows and “Buffalo Bill” Cody’s Wild West Show during the fair, which showed how inferior blacks and Indians were treated by their white lords. What seems funny, in retrospect, was the recruiting of Columbus for this effort. He was, after all, a leader of the Spanish and not an American in Roosevelt’s sense–certainly not English-speaking and certainly not Protestant. He was a spokesperson for things Roosevelt considered almost as despicable as the inferior races of the Orient. Columbus, a Catholic and a bit of a mystic, was an enthusiastic supporter of a regime that had just established the Inquisition, seen the election of a Spanish Pope named Borja (Borgia in Italy), expelled Jews, crushed Moslems and was planning to revive a Crusade to conquer Jersusalem. Why was this fellows, of all people, standing on top of the White City of good WASP values?

Columbus had arrived there by a long process of distortion and misreading, symbolized by the popularity in the United States of Washington Irving’s biography of the man. Irving, who wrote his book in Spain, had a hearty distaste for the Catholic Church, and he cast Columbus as a secular opponent of ecclesiastical superstition. Here was born the idea that Church officials opposed the voyage of Columbus because they thought the earth was flat. (Irving thought Columbus’ journey over the Atlantic somehow demonstrated the sphericity of the earth–an empirical feat not accomplished until Magellan’s circumnavigation.) Actually, in Columbus’ day, no one of any importance thought the earth was flat. Irving just seized a dramatic way of separating Columbus from his Church.